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CTTC Webinar - Dr. Antonio Colecchia
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When: November 6, 2019
9:00 am PT / 12:00pm ET
Where: Canada

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Wednesday, November 6, 2019
9:00am PT/12:00pm ET

The Potential Role of Liver Stiffness Measurement using FibroScan in the Diagnosis of VOD

Antonio ColecchiaMD (Borgo Trento University Hospital, Verona, Italy)

Speaker Biography:
Antonio Colecchia is Head of the Gastroenterology Unit at University Hospital Verona, Italy. He is also an Aggregate Professor of Hepatology at University Hospital Verona. Professor Colecchia obtained his medical degree at the University of Bologna, Italy, before specialising in gastroenterology and digestive endoscopy. Subsequently he joined the faculty at Policlinico S. Orsola, part of the University of Bologna in the Abdominal Ultrasound and Gastroenterology Ward, before he assumed his current position in 2017. Professor Colecchia’s research interests focus on the diagnosis and treatment of liver cirrhosis, hepatocellular carcinoma, portal hypertension, with a particular interest in imaging techniques for liver diseases, including ultrasound, elastometry and elastosonography. He is the coordinator of the ElastoVOD study, an Italian multicentre trial on the role of elastometry in predicting complications following haematopoietic stem cell transplantation, including veno-occlusive disease. A member of the European Association for the Study of the Liver and the Vascular Liver Disease Group, Professor Colecchia is well published in the medical literature, with more than 125 articles in international peer-reviewed journals. 

Veno-occlusive disease (VOD), known also as sinusoidal obstruction syndrome (SOS), is one of the main complications of hematopoietic stem cell transplantation (HSCT). Clinical diagnosis, by the recent European Bone Marrow Transplantation (EBMT) Criteria, is the reference for VOD/SOS diagnosis; however, increasing evidence suggests an emerging role of several imaging methods, that could help the clinician in VOD/SOS assessment. The main studies revolve around ultrasound (US) with Doppler evaluation, identifying numerous findings suggestive for VOD/SOS; however, their accuracy and validation is still suboptimal and controversial. 

Elastography, a new technique measuring the liver stiffness (LSM) represents a recent and promising approach for staging liver disease and to predict the presence of portal hypertension. VOD is a typical disease in which post sinusoidal portal hypertension developing and driving the major part of the symptoms. Keep in mind these characteristics of VOD and the capacity of Elastography in predicting portal hypertension through measurement of LSM, this new tool has been used in setting of HSCT. Elastography allowed with successful an early diagnosis of VOD/SOS. In-fact some recent studies demonstrated that elastography predicted VOD development some days before the appearance of clinical signs of VOD, in a preclinical phase. If these preliminary experiences will be confirmed in further studies on larger population, elastography could be useful to perform a pre-clinical diagnosis of VOD favouring early specific treatment aimed to improve survival rate.

Learning Objectives:

1. Overview of what Elastography/Liver Stiffness Measurement is
2. Understand the value LSM has in the diagnosis of VOD/SOS
3. Understand the current data using FibroScan on diagnosing VOD/SOS


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